ChloroquineV1, Main, Exploration, bibRecord, 001C12

Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.

Identifieur interne : 001C12 ( Main/Exploration ); précédent : 001C11; suivant : 001C13

Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.

Auteurs : Wassim Daher [France] ; Christophe Biot [France] ; Thierry Fandeur [France] ; Helene Jouin [France] ; Lydie Pelinski [France] ; Eric Viscogliosi [France] ; Laurent Fraisse [France] ; Bruno Pradines [France] ; Jacques Brocard [France] ; Jamal Khalife [France] ; Daniel Dive [France]

Source :

Malaria Journal [ 1475-2875 ] ; 2006.

RBID : Hal:inserm-00091291

Abstract

BACKGROUND: Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine (CQ) resistance problem. FQ revealed to be equally active on CQ-sensitive and CQ-resistant Plasmodium falciparum laboratory strains and field isolates. FQ is also curative on rodent malaria parasites. As FQ will be tested in patients, the potential for resistance to this drug was evaluated. METHODS: The relationship between CQ-resistant transporter gene genotype and susceptibility to FQ were studied in 33 Cambodian P. falciparum field isolates previously studied for their in vitro response to CQ. In parallel, the ability of the CQ-resistant strain W2, to become resistant to FQ under drug pressure was assessed. RESULTS: The IC50 values for FQ in field isolates were found to be unrelated to mutations occurring in the P. falciparum chloroquine resistance transporter (PfCRT) or to the level of expression of the corresponding mRNA. In vitro, under a drug pressure of 100 nM of FQ, transient survival was observed in only one of two experiments. CONCLUSION: Field isolates studies and experimental drug pressure experiments showed that FQ overcomes CQ resistance, which reinforces the potential of this compound as a new antimalarial drug.

Url:

https://www.hal.inserm.fr/inserm-00091291

DOI: 10.1186/1475-2875-5-11

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.</title>
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<country>France</country>
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<author><name sortKey="Fraisse, Laurent" sort="Fraisse, Laurent" uniqKey="Fraisse L" first="Laurent" last="Fraisse">Laurent Fraisse</name>
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<country>France</country>
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<author><name sortKey="Pradines, Bruno" sort="Pradines, Bruno" uniqKey="Pradines B" first="Bruno" last="Pradines">Bruno Pradines</name>
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            </address>
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<country>France</country>
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<author><name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name>
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<country>France</country>
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</author>
<author><name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
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          <desc>            <address>              <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine>
              <country key="FR"></country>
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<country>France</country>
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</author>
<author><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID">          <orgName>Schistosomiase, paludisme et inflammation</orgName>
          <desc>            <address>              <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine>
              <country key="FR"></country>
            </address>
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          <date type="start">1894</date>
          <desc>            <address>              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
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          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
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          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
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          <idno type="IdRef">026404389</idno>
          <orgName>Université de Lille, Droit et Santé</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>42 rue Paul Duez 59000 Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille2.fr/</ref>
          </desc>
        </org>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1186/1475-2875-5-11</idno>
<series><title level="j">Malaria Journal</title>
<idno type="ISSN">1475-2875</idno>
<imprint><date type="datePub">2006</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">              <p>BACKGROUND: Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine (CQ) resistance problem. FQ revealed to be equally active on CQ-sensitive and CQ-resistant Plasmodium falciparum laboratory strains and field isolates. FQ is also curative on rodent malaria parasites. As FQ will be tested in patients, the potential for resistance to this drug was evaluated. METHODS: The relationship between CQ-resistant transporter gene genotype and susceptibility to FQ were studied in 33 Cambodian P. falciparum field isolates previously studied for their in vitro response to CQ. In parallel, the ability of the CQ-resistant strain W2, to become resistant to FQ under drug pressure was assessed. RESULTS: The IC50 values for FQ in field isolates were found to be unrelated to mutations occurring in the P. falciparum chloroquine resistance transporter (PfCRT) or to the level of expression of the corresponding mRNA. In vitro, under a drug pressure of 100 nM of FQ, transient survival was observed in only one of two experiments. CONCLUSION: Field isolates studies and experimental drug pressure experiments showed that FQ overcomes CQ resistance, which reinforces the potential of this compound as a new antimalarial drug.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Centre-Val de Loire</li>
<li>Région Centre</li>
</region>
<settlement><li>Tours</li>
</settlement>
<orgName><li>Centre Val de Loire Université</li>
<li>Université de Tours</li>
</orgName>
</list>
<tree><country name="France"><noRegion><name sortKey="Daher, Wassim" sort="Daher, Wassim" uniqKey="Daher W" first="Wassim" last="Daher">Wassim Daher</name>
</noRegion>
<name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
<name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name>
<name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<name sortKey="Fandeur, Thierry" sort="Fandeur, Thierry" uniqKey="Fandeur T" first="Thierry" last="Fandeur">Thierry Fandeur</name>
<name sortKey="Fraisse, Laurent" sort="Fraisse, Laurent" uniqKey="Fraisse L" first="Laurent" last="Fraisse">Laurent Fraisse</name>
<name sortKey="Jouin, Helene" sort="Jouin, Helene" uniqKey="Jouin H" first="Helene" last="Jouin">Helene Jouin</name>
<name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
<name sortKey="Pelinski, Lydie" sort="Pelinski, Lydie" uniqKey="Pelinski L" first="Lydie" last="Pelinski">Lydie Pelinski</name>
<name sortKey="Pradines, Bruno" sort="Pradines, Bruno" uniqKey="Pradines B" first="Bruno" last="Pradines">Bruno Pradines</name>
<name sortKey="Viscogliosi, Eric" sort="Viscogliosi, Eric" uniqKey="Viscogliosi E" first="Eric" last="Viscogliosi">Eric Viscogliosi</name>
</country>
</tree>
</affiliations>
</record>

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Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.

Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.

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